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Another study investigating the effects of 4-HNE on cardiomyocyte DNA repair capacity reported that the activity of 8-oxoguanine DNA glycosylase 1 (OGG1), a key enzyme responsible for repairing oxidative DNA damage, was significantly reduced in the myocardium of db/db mice, accompanied by elevated 4-HNE adduct levels
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These thin, adhesive patches contain hundreds of microscopic needles that painlessly penetrate the stratum corneum and deliver their peptide payload directly into the epidermis and upper dermis
where they are burned for energy
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