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Photo by Wellblūm (@wellblumgroup) · November 16, 2025

Although many of the inflammatory pathways described for AD would apply directly to DS, there are some particular inflammatory genes on chromosome 21 that affect inflammatory responses in the DS brain, including a highly expressed CXADR gene, which functions as an adhesion molecule and is associated with endothelial tight junctions [127,128]

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Key sources include journalistic accounts of experiments ( [1] ) ( [2] ), conference reports ( [9] ) ( [29] ), and in-depth interviews with AI leaders ( [47] ) ( [26] )