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In addition to the significant role of 16S rRNA, the 23S rRNA in the large ribosomal subunit assumes critical functions in mediating interactions with tRNAs, elongation factors, peptide bond formation within the peptidyl-transferase center (PTC), and the facilitation of the folding and release of the nascent polypeptide chain through the exit tunnel

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1997 Aug;12(8):1622-8