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Additionally, even though Nrf2 activation was seen in vivo , aldosterone-treated rat kidneys showed significant DNA damage, showing that the response was insufficient to shield the animals from these side effects ( 5.3 Androgens hormone imbalance-associated oxidative stress Testosterone, the main male steroid hormone, causes spermatogenesis and secondary sexual characteristics
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The next section concerns the importance of biomarkers in the process of developing treatment strategies
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